In this talk, I will present quantum biological ICs for fundamental life sciences and predictive digital health. First, I will introduce a quantum plasmonic nanoscope that allows non-invasive optical imaging of quantum biological electron-transfer (QBET) dynamics in live cells. The quantum nanoscope is designed to capture the real-time QBET imaging of enzymes using Plasmon Resonance Energy Transfer (PRET) mechanism and quantized plasmon quenching dips in resonant Rayleigh scattering spectra. Second, I will discuss quantum biological ICs (QBICs) for ultrafast precision molecular diagnostic systems. The QBICs comprise three key elements: (1) ultrafast photonic amplifications of NA biomarkers; (2) signal amplifications of protein biomarkers; (3) a self-contained sample preparation from whole blood on chip, which allows a sample-to-answer readout platform for digital health and analytics. Third, I will also examine the important role of smart hybrid bioelectronics ICs (i.e. integrated silicon and silicone technologies) for integrated molecular diagnostics and therapeutics systems, which allow predictive digital health. If time permits, microphysiological analytics platforms (MAPs), or organs on chip, will be examined as innovative solutions in pathogenesis studies, personalized drug discovery, and therapeutics. In particular, the real-time imaging of pathogenesis and evolution of mini-brains and pancreatic islets MAP will be discussed along with the vision of personalized precision medicine.
Prof. Luke P. Lee received both his BA and PhD from UC Berkeley. He joined the faculty at the UC Berkeley in 1999 after more than a decade of industry experience. He became the Lester John and Lynne Dewar Lloyd Distinguished Professor of Bioengineering in 2005. He also served as the Chair Professor in Systems Nanobiology at the ETH Zürich from 2006 to 2007. He became Arnold and Barbara Silverman Distinguished Professor at Berkeley in 2010 and was reappointed again 2015. Lee is now a Tan Chin Tuan Centennial Professor, Director of the Biomedical Institute for Global Healthcare Research & Technology (BIGHEART), and Associate President (International Research and Innovation) at the National University of Singapore. He is a Fellow of the Royal Society of Chemistry and the American Institute of Medical and Biological Engineering. His work at the interface of biological, physical, and engineering sciences for medicine has been recognized by many honors including the IEEE William J. Morlock Award, NSF Career Award, Fulbright Scholar Award, and the HoAm Prize. Lee has over 350 peer-reviewed publications and over 60 international patents filed. His current research interests are quantum biological electron transfers in living organisms, molecular diagnostics of neurodegenerative diseases, and in vitro neurogenesis, with a focus both on studying fundamental quantum nanobiology and on solving ill-defined problems of global healthcare.